Combination of Therapies for Detoxification and Treatment of Chronic Fatigue, Fibromyalgia, and Other Chronic Diseases 

Chronic fatigue syndrome, fibromyalgia, and other chronic diseases such as auto-immune diseases, vascular and heart disease, diabetes, and arthritis have been on the rise

Toxins can be classified as inorganic (toxic heavy metals and transition metals), organic (pesticides, solvents, cigarette-related toxins), or biological (allergies, low-grade hidden infections).  Various toxins may be cleared by the liver detoxification pathways.  It is general opinion by Environmental Medicine groups such as the American Academy of Environmental Medicine, that unfortunately these toxins may potentially overload detoxification pathways, potentially aggravating symptoms.  Infections may be a toxic foci, which until naturally resolved by the system or treated, may potentially  attribute to chronic disease such as arthritis or heart disease. 

Our combination of detoxification therapies is comprehensive in that toxic metals may be pulled out of the tissues and excreted (intravenous chelation therapy), low-grade infections may be treated (high-dose vitamin C therapy or oxidative medicine), and the liver, kidneys, and lymphatic system may be supported.  A temporary low-allergen diet may recommended in patients.  

Chelation therapy has been used widely as an alternative treatment for cardiovascular disease.  It is becoming increasingly recognized that its benefit comes largely from the detoxification of free-radical generating heavy metals.  Therapy may involve the administration of intravenous EDTA, intravenous DMPS, or oral DMSA, depending on the metals present.  Chelation therapy reduces the body's burden of lead, cadmium, mercury, arsenic, and aluminum amongst others.  

Support of liver detoxification comes from recognizing the biochemistry of natural detoxification in this organ.  Medical foods and supplements may be used to support Phase I reactions and Phase II liver detoxification pathways. 

In conclusion, if a patient has a history of chronic toxin exposure, such as from smoking, or has a chronic degenerative disease, detoxification may be an important component of a comprehensive treatment plan.  Stimulation of the body's natural healing ability may involves removing these toxic obstacles to cure; thus detoxification may be indicated.

Signs that detoxification may be indicated:

·Chronic fatigue without improvement from sleep

·Chronic generalized pains in the muscles and the joints

·Recurrent vascular headaches, cluster headaches, migraines

·History of toxin exposure such as cigarette smoke

·Previous benefit from milder detoxification programs


Immunological diseases which indicate candidates for this treatment:

·Auto-immune diseases

·Rheumatoid arthritis


·Seasonal and food allergies

·Candida related complex

·Chronic infections (including Chlamydia-associated heart disease)

·Eczema, psoriasis, other skin lesions


Evidence for role of infections in Auto-immune diseases, heart disease (only a few of many more):

·Assessment of systemic inflammation and infective pathogen burden in patients with cardiac syndrome X.

Am J Cardiol. 2004 Jul 1;94(1):40-4.

·High prevalence of Chlamydia pneumoniae seropositivity in Mexican patients with ischemic heart disease.

Arch Med Res. 2004 Jul-Aug;35(4):318-23.

 ·The prevalence of Mycoplasma fermentans in patients with inflammatory arthritides.

Rheumatology (Oxford). 2001 Dec;40(12):1355-8.

·Mycoplasma fermentans in rheumatoid arthritis and other inflammatory arthritides.

J Rheumatol. 2000 Dec;27(12):2747-53.


Evidence for IV chelation, vitamins/minerals for cardiovascular disease

Issa OM1, Roberts R2, Mark DB2, Boineau R3, Goertz C4, Rosenberg Y5, Lewis EF6, Guarneri E7, Drisko J8, Magaziner A9, Lee KL2, Lamas GA10. 2018. Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT). Am Heart J. 2018 Jan;195:70-77.

Diaz D1, Fonseca V2, Aude YW3, Lamas GA1. 2018. Chelation therapy to prevent diabetes-associated cardiovascular events. Curr Opin Endocrinol Diabetes Obes. 2018 Aug;25(4):258-266.


Evidence for Chelation therapy

Alessandro Fulgenzi and Maria Elena Ferrero  2019. EDTA Chelation Therapy for the Treatment of Neurotoxicity Int. J. Mol. Sci. 20(5), 1019.


Bamonti, F.; Fulgenzi, A.; Novembrino, C.; Ferrero, M.E. Metal chelation therapy in rheumathoid arthritis:

A case report: Successful management of rheumathoid arthritis by metal chelation therapy. Biometals 2011.


Fulgenzi, A.; Zanella, S.G.; Mariani, M.M.; Vietti, D.; Ferrero, M.E. A case of multiple sclerosis improvement

following removal of heavy metal intoxication: Lessons learnt from Matteo’s case. Biometals 2012, 25, 569–576.


Fulgenzi, A.; Vietti, D.; Ferrero, M.E. Aluminium involvement in neurotoxicity. Biomed. Res. Int. 2014, 2014,



Fulgenzi, A.; De Giuseppe, R.; Bamonti, F.; Vietti, D.; Ferrero, M.E. Efficacy of chelation therapy to remove

aluminium intoxication. J. Inorg. Biochem. 2015, 152, 214–218.


Fulgenzi, A.; De Giuseppe, R.; Bamonti, F.; Ferrero, M.E. Improvement of oxidative and metabolic parameters

by cellfood administration in patients affected by neurodegenerative diseases on chelation treatment.

Biomed. Res. Int. 2014, 2014.


Roussel, A.M.; Hininger-Favier, I.;Waters, R.S.; Osman, M.; Fernholz, K.; Anderson, R.A. EDTA Chelation

therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation. Altern. Med.

Rev. 2009, 14, 56–62.


Evidence for detoxification improving risk factors and healing chronic disease (brief examples of many):

·[Leaded gasoline and cancer mortality]

Schweiz Med Wochenschr. 1976 Apr 10;106(15):503-6.

·Association between malignant tumors of the thyroid gland and exposure to environmental protective and risk factors.

Rev Environ Health. 2000 Jul-Sep;15(3):337-58. 

·Organophosphorus ester-induced chronic neurotoxicity. Arch Environ Health. 2003 Aug;58(8):484-97. Review.


Evidence for sauna therapy

Masuda A1, Kihara T, Fukudome T, Shinsato T, Minagoe S, Tei C.  2005.  J Psychosom Res.

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome. Apr;58(4):383-7.

Beever R1.  2009.  Far-infrared saunas for treatment of cardiovascular risk factors: summary of published evidence.

Can Fam Physician. Jul;55(7):691-6.

Beever R1. 2010. The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus.

J Altern Complement Med. Jun;16(6):677-81.

Soejima Y1, Munemoto T, Masuda A, Uwatoko Y, Miyata M, Tei C. 2015. Effects of Waon therapy on chronic fatigue syndrome: a pilot study. Intern Med. 2015;54(3):333-8.

Isomäki H1. 1988.  The sauna and rheumatic diseases. Ann Clin Res. 1988;20(4):271-5.

Matsushita K1, Masuda A, Tei C. 2008.  Efficacy of Waon therapy for fibromyalgia. Intern Med. 2008;47(16):1473-6.

Matsumoto S1, Shimodozono M, Etoh S, Miyata R, Kawahira K. 2011.  Effects of thermal therapy combining sauna therapy and underwater exercise in patients with fibromyalgia.

Complement Ther Clin Pract. Aug;17(3):162-6.

Laukkanen T1,2, Kunutsor SK3,4, Khan H5, Willeit P6,7, Zaccardi F8, Laukkanen JA.  2018.  Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study.  BMC Med. 2018 Nov 29;16(1):219.

Kunutsor SK1, Khan H2, Zaccardi F2, Laukkanen T2, Willeit P2, Laukkanen JA2. 2018.  Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study.  Neurology. 2018 May 29;90(22):e1937-e1944.

J Hum Hypertens. 2018 Feb;32(2):129-138. doi: 10.1038/s41371-017-0008-z. Epub 2017 Dec 21.

Acute effects of sauna bathing on cardiovascular function.

Laukkanen T1, Kunutsor SK2, Zaccardi F3, Lee E4, Willeit P5,6, Khan H7, Laukkanen JA8,9.

Laukkanen JA1,2, Laukkanen T3. 2018. Sauna bathing and systemic inflammation.  Eur J Epidemiol. Mar;33(3):351-353.

Zaccardi F1, Laukkanen T2, Willeit P3,4, Kunutsor SK5, Kauhanen J2, Laukkanen JA2,6. 2017. Sauna Bathing and Incident Hypertension: A Prospective Cohort Study. Am J Hypertens. Nov 1;30(11):1120-1125.

Laukkanen T1, Kunutsor S2, Kauhanen J1, Laukkanen JA1. 2017. Sauna bathing is inversely associated with dementia and Alzheimer's disease in middle-aged Finnish men.  Age Ageing. 2017 Mar 1;46(2):245-249.

Tei C1, Imamura T, Kinugawa K, Inoue T, Masuyama T, Inoue H, Noike H, Muramatsu T, Takeishi Y, Saku K, Harada K, Daida H, Kobayashi Y, Hagiwara N, Nagayama M, Momomura S, Yonezawa K, Ito H, Gojo S, Akaishi M, Miyata M, Ohishi M; WAON-CHF Study Investigators. 2016. Waon Therapy for Managing Chronic Heart Failure - Results From a Multicenter Prospective Randomized WAON-CHF Study. Circ J. 2016;80(4):827-34.

Laukkanen T1, Khan H2, Zaccardi F3, Laukkanen JA1. 2015. Association between sauna bathing and fatal cardiovascular and all-cause mortality events. JAMA Intern Med. 2015 Apr;175(4):542-8.