Chelation and ozone treatment (chelox or chezone) for cardiovascular diseases - one of the most rewarding conditions to treat

Naturopathic medicine excels at treating many different conditions, because the premise of a holistic approach is to make sure each and every cell is getting the good molecules it needs, and getting rid of the toxic molecules it doesn't. Such an approach makes sense for many patients because it supports health, allowing the body to heal and to respond more appropriately to natural medications.

Of course, the cells derive all of their most basic nutritional needs, including oxygen, from transport of blood in the blood vessels. A large part, but not all, of the cell's metabolic and environmental toxins are also carried away from the cell by the blood.

So when a patient presents with one of the most common forms of cardiovascular disease,coronary artery disease, I immediately see a patient who very likely has tissue that is hungry for oxygen and nutrients. Chezone treatment combines both chelation and ozone to treat this effectively and quickly. Chelox is a generic term for the combination of chelation and an oxidative treatment, where chezone is taught by Frank Shallenberger MD and refers to chelation with ozone therapy. Chezone is a popular and effective treatment for many illnesses, but not frequently offered by other doctors. Here in Vancouver I often get chezone patients from the Seattle area.

Ozone therapy improves oxygen delivery and circulation by:

1. decreasing the viscosity and thickness of the blood, so that it can navigate the small capillaries better, and is easier to pump

2. improves the ability of red blood cells to unload oxygen to the tissues. This persists long after the course of treatments is completed

3. decreases inappropriate inflammation in the blood, allowing for the formation of nitric oxide to help the arteries dilate, further improving blood flow

Chelation therapy improves circulation by:

1. removing heavy metals such as lead, which impair the formation of nitric oxide. Nitric oxide is produced by the lining of the blood vessels as a signal to help arteries relax and dilate, improving circulation

2. delivering high doses of nutrients such as magnesium, acting as a natural calcium channel blocker to keep arteries dilated and relaxed

I will usually put a patient who has coronary artery disease on a naturopathic program that involves both of these treatments. Often, I will combine the two treatments on the same day such that I administer an ozone treatment and follow this immediately with an EDTA chelation treatment (chelox therapy, or chezone). Usually a treatment program would involve up to 20-30 treatments over the course of a few months, but the patient will usually feel a noticeable difference in their symptoms after 3-4 ozone treatments (it can take a while longer if EDTA chelation is done alone).

The ozone procedure generally takes 30 minutes to complete. Once the ozone therapy is complete, an EDTA chelation bag is immediately hung up, taking 45-90 minutes to infuse in. 

What to expect?

I was recently asked if there were any testimonials that patients had submitted regarding naturopathic treatment with chelation and ozone for coronary artery disease. I gave my usual response, which is that other patients generally will share their stories if they are seated beside you while getting treatment, but testimonials don't go far in any form of medicine because each patient is different. Then I typically go into how we should be looking at data instead of testimonials, and generally I will give the following infomation which looks into treatments almost identical to my naturopathic programs for coronary artery and heart disease (it is quite repetitive so you may want to skip past the summaries after reading a few):


J Card Surg reported that rat hearts had less damage from reperfusion of blood if the heart was treated with ozone. Reperfusion injury is important in patients who receive a surgical intervention that rapidly restores blood flow. Such injury is thought to be caused by an inability of the heart muscle to adapt to free-radical stress: ozone therapy is known to increase the ability of cells to respond to free radical stress.


Free Radic Biol Med journal reported on 22 patients who had 15 treatments of ozone by the procedure above. They had all had heart attacks within the previous year, and all had evidence of decreased intracellular antioxidant proteins such as glutathione peroxidase. After the treatment course, total cholesterol and LDL cholesterol (bad cholesterol) decreased significantly. More importantly, the antioxidant capability of the blood as measured by glutathione peroxidase increased.


81 patients were studied in Russia, all of whom had detectable blockages in their arteries. After a series of ozone treatments, the blood was less likely to clot, had decreased platelet activity, and had increased levels of enzymes and proteins that dissolved clots.


An Italian study of 72 patients who had blockages in the arteries feeding their legs, looked at different ways of administering ozone versus a control (no treatment group). They found that the ozone treatment groups, but not the control group, had significant improvements in walking speed and difference, and patients could increase walking speed to 2.5 km/hr. The authors believed the positive changes were do to changes in the microcirculation, as in the ability of the blood to unload oxygen.


Another Italian study looked at 15 patients who had blockages in the arteries feeding the legs that were so severe that revascularization surgery (eg bypass) was not an option. They found that ozone therapy was able to decrease the number of patients requiring amputation by 50%.


A Russian study of 85 patients who had progressive angina (chest pain due to lack of blood flow to the heart) and irregular heartbeats showed ultraviolet blood irradiation (similar to ozone therapy, which I also do) increased blood flow to the heart and was associated with favorable clinical improvements.


Another Russian study looked at the use of ultraviolet blood irradiation in cardiac rehab setting. They found the treatment to decrease cholesterol, decrease blood glucose, increase exercise tolerance, and improve the clotting parameters of the blood. Pretty well-rounded results.


A German study of 70 male patients who had severe progressive angina, 2/3rds of which had previously had a heart attack, and many of which who required more than 10 doses of nitroglycerin per day, found that UV blood irradiationimproved the majority of patients. This is after a 2 week trial of intensive drug therapy. They also found that markers of inflammation and infection were markedly cleared after the UV therapy.


There is also plenty of information on chelation therapy and heart disease in patients, and I have summarized some of the literature here in another newsletter.


To answer the question of what to expect for a patient, we can simply say that the condition of the patient improves, usually after a few treatments, although the full course can take a few months. Since we are doing a therapy that improves oxygen delivery, and removes metabolic poisons, the ability of all the cells and tissues to generate energy is restored. The net effect is therefore a decrease in angina symptoms, improvement in blood flow, and more energy.


While it may be that revascularization therapy with bypass surgery or angioplasty gives almost immediate results, such therapy only treats one lesion and does not treat the entire circulation. It's like having a houseful of rusting, corroding pipes, and then waiting for one joint in the plumbing to leak or to get corroded through, instead of slowly, deliberately, effectively treating the entire plumbing system.


This naturopathic approach to coronary artery and heart disease can be summarized in the following picture:

The above series of reactions is how each cell generates energy from calories in our food and the oxygen we breathe. 


Ozone stimulates the cycle to run faster, and increases the bottom reaction (oxidative phosphorylation), and improves oxygen delivery. Chelation therapy removes the metal toxins (in red) that poison and slow down the cycle. The chelation IV bag also provides the nutrients (in green) that feed the cycle.


This is why the combination of ozone therapy and EDTA chelation therapy as a naturopathic program for coronary artery and heart disease is so rewarding. The combination of therapies improves the most fundamental problem in such a disease, which is energy generation. And it does so by providing the nutrients for this to happen, and removing the toxins that block it.


Is chelox / chezone therapy the only thing I have to do?


Of course, chelox / chezone therapy is only part of a comprehensive naturopathic program. During the initial consultation and exam, other important factors in health are addressed, such as dietary and lifestyle factors, particularly graduated exercise. In many cases though, chelox therapy (combination of EDTA chelation and ozone therapy), is the mainstay of the program until symptoms and the condition are improved significantly. Risk factor reduction in terms of lowering cholesterol (within reason), lowering blood pressure, finding the cause of inflammation, still need to be addressed as they are important as well.


What is the frequency of treatments?


Usually, once we have our lab reports back, treatments are given twice a week. Many times out of town patients will require more frequent treatment for practicality reasons, and in these cases chelation is given 3-5 times a week, and ozone therapy 5-7 times a week. 


How is the patient monitored?


When I administer the treatment, after the needle is in the vein, I will pull blood every few treatments to ensure that the body is handling the stimulation and detoxification well. Particularly, I make sure the kidneys are handling the detoxification well. Often times, a urine test is done to confirm that the chelation therapy is in fact removing large amounts of metal toxins. This urine test also allows me to give an estimation of the length of treatment.