Chronic lyme disease test and lyme symptoms


Lyme disease is caused by infection with a spirochete called Borrelia burgerfori. In Europe often lyme disease is caused by another species of Borrelia and thus medical literature on both lyme disease test and treatment may or may not apply in North America).


Lyme disease is often a great mimicker of other illnesses, and thus can often go undetected while patients get suboptimal treatment for another condition. Examples where this may be the case include chronic fatigue syndrome and fibromyalgia, various types of arthritis, and many cases of neuropathic pain.


Lyme symptoms


Again, lyme disease mimicks many other chronic conditions. The spirochete that causes lyme disease, Borrelia, is unique in that it has more lipoproteins coded for in its DNA than any other organism, over 100. Furthermore, very few of the genes code for proteins related to biosynthesis. In plain english this means that lyme symptoms can be severe and chronic, with lots of pain and inflammation due to the unusually high number of lipoproteins present. Further, in chronic lyme the spirochete is adept at living “with” the host cells and multiplying slowly, since it does not have the proteins for biosynthesis it relies on the host cells of the patient to provide nutritional requirements.


The conventional medicine textbook Harrison’s Principle’s of Internal Medicine lists the following lyme symptoms:


  • classic erythema migrans rash (bull’s eye rash)

  • coinfection with anaplasma or babesia may indicate changes on a regular complete blood count, including low platelets (thrombocytopenia) or low white blood cells (leukopenia)

  • facial palsy (similar to Bell’s palsy with facial muscle droop)

  • arthritis or pain in the joints

  • symptoms of chronic fatigue syndrome or fibromyalgia!


Very limited group of symptoms, but relatively specific especially when combined with the right lyme disease test.


The International Lyme and Associated Disease group has the following symptoms published in their guidelines: (note ILADS is an unconventional group which has gone far to educate doctors and the public about proper chronic lyme treatment and lyme diagnosis)


CNS type lyme symptoms:


  • memory loss

  • fatigue

  • headache

  • depression

  • sleep disturbance

  • irritability


General lyme symptoms:


• Fatigue

• Low grade fevers, ‘hot flashes’ or chills

• Night sweats

• Sore throat

• Swollen glands

• Stiff neck

• Migrating arthralgias, stiffness and, less commonly, frank


• Myalgia

• Chest pain and palpitations

• Abdominal pain, nausea

• Diarrhea

• Sleep disturbance

• Poor concentration and memory loss

• Irritability and mood swings

• Depression

• Back pain

• Blurred vision and eye pain

• Jaw pain

• Testicular/pelvic pain

• Tinnitus

• Vertigo

• Cranial nerve disturbance (facial numbness, pain, tingling,

palsy or optic neuritis)

• Headaches

• ‘Lightheadedness’

• Dizziness


Clearly the ILADS group of symptoms is much more broad and encompassing, and in my mind it becomes especially important to exclude other causes of illness, and have objective, lab based evidence of infection to support chronic lyme diagnosis as the cause of the lyme disease symptoms.



Lyme disease test


The conventional standard for lyme disease diagnosis confirmation is a two-tiered test consisting of an ELISA test for lyme first, and if “equivocal” or positive, then confirmation by western blot testing. In Canada, if the ELISA is negative then the diagnosis is considered excluded by most conventional physicians.


The ILADS guidelines for a proper lyme disease test involve the use of a western blot with possibly less strict criteria for interpretation. In general, the western blot lyme disease test measures antibodies or immune system proteins against specific antigens (foreign molecules). Some of these antigens are very specific for lyme, and others are shared with other spirochete infections. Conventional positives for a western blot lyme disease test involve 2 of 3 specific IgM antibodies and 5 of 10 specific IgG antibodies.

There is no perfect lyme disease test, and diagnosis can be made based on strong clinical suspicion. The western blot is very helpful though, and for certain coinfections, it is important to test as treatment for chronic lyme disease may not cover certain infections (such as Babesia). 


In my own practice, if chronic lyme is suspected, then the lyme disease test to start with is the western blot for both IgG and IgM. If there is a swollen joint that is painful, then the joint fluid may be tapped and sent for analysis to see if the Borrelia DNA is present. Occasionally, tests for the immune system and its suppression can be used (CD57 activity). I do tend to test for coinfections depending on the symptoms that present, and use tests that look for the immune system response to these infections. Some labs have non-standard stains that can be extremely helpful as they directly visualize coinfections, such as Bartonella spp., and can directly stain DNA and show large biofilm communities of infection.  Both the treatment of biofilm and the coinfections becomes important so that extended antibiotic therapy is not the only option.