Coronary artery disease is the most common cardiovascular affliction in our society, and is the leading cause of death. It is a problem of decreased blood flow and oxygen delivery, because of narrowed arteries. Atherosclerosis is the process of the narrowing, and describes plaque buildup on the lining of the arteries. This plaque buildup is made of calcium, fats, metals, and immune cells. If the plaque is subject to stress and inflammation, it may become a vulnerable plaque, rupture, and cause a clot that leads to a heart attack.

Tests for an actual heart attack in-occurrence are done in the ER. This may include an ECG and blood tests to check for proteins that leak into the blood stream during a heart attack.  


Naturopathic Treatment of Coronary Artery Disease

•Nutritional and herbal medications can be used to relax the muscular artery walls, decrease positive risk factors, decrease the thickness of blood, and with the goal of reducing further plaque from building up.

•Exercise and diet changes may reduce risk and help to maintain benefits from treatment.

Chelation therapy: Removes lead, which is a poison for the enzyme (nitric oxide synthase). This enzyme creates your body's natural "nitroglycerin", to relax artery walls.  A recent study of 14,000 patients showed that elevated blood lead, even at 1/20th the normal reference range, can be associated with a 2x increased risk of stroke. The NIH trial on chelation therapy (Trial to Assess Chelation Therapy; Lamas GA et al, JAMA 2013) showed good promise especially for a subset of patients - those who had already had a heart attack as well as had been diagnosed with diabetes.

Oxidative therapy (e.g. ozone by major autohemotherapy) may be very useful with data that shows decreased angina, leg pain, blood pressure; with improvement in blood viscosity patterns.


Evidence for IV chelation, vitamins/minerals for cardiovascular disease

Lamas GA, Goertz C, Boineau R, Mark DB, Rozema T, Nahin RL, Lindblad L, Lewis EF, Drisko J, Lee KL; TACT Investigators. 2013. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA. 2013 Mar 27;309(12):1241-50.

Issa OM, Roberts R, Mark DB, Boineau R, Goertz C, Rosenberg Y, Lewis EF, Guarneri E, Drisko J, Magaziner A, Lee KL, Lamas GA. 2018. Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT). Am Heart J. 2018 Jan;195:70-77.

Diaz D, Fonseca V, Aude YW, Lamas GA. 2018. Chelation therapy to prevent diabetes-associated cardiovascular events. Curr Opin Endocrinol Diabetes Obes. 2018 Aug;25(4):258-266.


References: Ozone

Bocci V, Zanardia I, Valacchi G, Borrelli E, Travagli V. 2015. Validity of Oxygen-Ozone Therapy as Integrated Medication Form in Chronic Inflammatory Diseases. Cardiovasc Hematol Disord Drug Targets. 2015;15(2):127-38.

Giunta R, Coppola A, Luongo C, Sammartino A, Guastafierro S, Grassia A, Giunta L, Mascolo L, Tirelli A, Coppola L. 2001. Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease. Ann Hematol. 2001 Dec;80(12):745-8.

Valacchi G, Bocci V. 2000. Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells. Mediators Inflamm. 2000;9(6):271-6.

Inal M, Dokumacioglu A, Özcelik E, Ucar O. 2011. The effects of ozone therapy and coenzyme Q₁₀ combination on oxidative stress markers in healthy subjects. Ir J Med Sci. 2011 Sep;180(3):703-7.

Wu XN, Zhang T, Wang J, Liu XY, Li ZS, Xiang W, Du WQ, Yang HJ, Xiong TG, Deng WT, Peng KR, Pan SY. 2016. Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction. Neural Regen Res. 2016 Jul;11(7):1115-21.

Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA. 2017. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017 Oct 17;7(3):212-219.

Molinari F, Simonetti V, Franzini M, Pandolfi S, Vaiano F, Valdenassi L, Liboni W. 2014. Ozone autohemotherapy induces long-term cerebral metabolic changes in multiple sclerosis patients. Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(3):379-89.


References: Ozone (Major Autohemotherapy, other forms ozone therapy) & Diabetes (cardiovascular disease risk factor)

Bocci V, Zanardi I, Huijberts MS, Travagli V. 2011.  Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy. Diabetes Metab Syndr. 2011 Jan-Mar;5(1):45-9.

Bocci V, Zanardi I1, Huijberts MS, Travagli V. 2014. It is time to integrate conventional therapy by ozone therapy in type-2 diabetes patients. Ann Transl Med. 2014 Dec;2(12):117.

Bocci V, Zanardi I, Huijberts MS, Travagli V4. 2014. Diabetes Metab Syndr. 2014 An integrated medical treatment for type-2 diabetes.  Jan-Mar;8(1):57-61.

de Monte A, van der Zee H, Bocci V. 2005. Major ozonated autohemotherapy in chronic limb ischemia with ulcerations. J Altern Complement Med. 2005 Apr;11(2):363-7.

Braidy N, Izadi M, Sureda A, Jonaidi-Jafari N, Banki A, Nabavi SF, Nabavi SM5. 2018. Therapeutic relevance of ozone therapy in degenerative diseases: Focus on diabetes and spinal pain. J Cell Physiol. 2018 Apr;233(4):2705-2714.


Other references

Fulgenzi, A.; De Giuseppe, R.; Bamonti, F.; Ferrero, M.E. Improvement of oxidative and metabolic parameters by cellfood administration in patients affected by neurodegenerative diseases on chelation treatment.  Biomed. Res. Int. 2014, 2014.